Epidermal Growth Factor Rescues Endothelial Dysfunction in Primary Human Tissues in Vitro

R Hastie; S Tong; NJ Hannan; F Brownfoot; P Cannon; TJ Kaitu'U-Lino

Journal article

Epidermal Growth Factor Rescues Endothelial Dysfunction in Primary Human Tissues in Vitro

R Hastie, S Tong, NJ Hannan, F Brownfoot, P Cannon, TJ Kaitu'U-Lino

Reproductive Sciences | SAGE PUBLICATIONS INC | Published : 2017

DOI: 10.1177/1933719116681516

Abstract

Preeclampsia is a hypertensive disorder of pregnancy, responsible for over 60 000 maternal deaths annually. Endothelial dysfunction is a central aspect to its pathophysiology, and currently, no medical therapeutic is available for its treatment. In this study, we aim to investigate the effect of epidermal growth factor (EGF) on endothelial dysfunction using primary human tissues. We performed a number of in vitro assays that mimic the vascular endothelial dysfunction that occurs in preeclampsia. Epidermal growth factor reduced the expression of vascular cell adhesion molecule-1, a marker of endothelial dysfunction, after insult with tumor necrosis factor α (TNF-α) or serum from women with pr..

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University of Melbourne Researchers

Stephen Tong Author

Natalie Hannan Author

Fiona Brownfoot Author

Ping Cannon Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by an Australian Post Graduate Award as well as the National Health and Medical Research Council of Australia providing salary (#1062418 to T.K.L, #1050765 to S.T.). N.J.H is supported by a CR Roper Fellowship from the University of Melbourne.